Looking to ease mild depression? The herb St. John’s wort appears to reduce the production of cortisol (a stress hormone) and boost the action of neurotransmitters that help lighten mood.

The staff at Massachusetts General Hospital advises that the herb is most effective for mild to moderate depression and less so for people with severe depression.

It can interact with certain prescription drugs, so check with a healthcare practitioner before taking St. John’s wort. It should not be used with most antidepressant drugs.